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In 2025, nutra hasn’t gotten any easier: approval rates are low, traffic in Latin America is unstable, and competition on old “hits” like weight loss or you-know-what enhancement is through the roof. If you feel that standard offers are no longer profitable, it’s time to focus on underrated segments — sub-verticals that don’t get much attention but can still deliver 30–40% approval with the right approach. Below is a list of such niches with ideas for creatives and landers. You’ll need to pick GEOs where they “pop” manually.
With approval rates dropping on traditional offers and classic nutra themes becoming oversaturated, media buyers are starting to look for new angles. Offers like weight loss, hypertension, and potency have long been overheated: creatives burn out quickly, traffic gets expensive, and Facebook bans campaigns almost at the idea stage. In this environment, many overlook one of the simplest and most effective niches — treatment for nail and skin fungus.
This is a niche that has long remained on the sidelines, despite the issue being widespread and extremely unpleasant. Fungus isn’t just a cosmetic defect — it’s pain, discomfort, foul odor, and most importantly, shame. Shame plays a key role here. People don’t want to talk about it openly, they’re embarrassed to see a doctor, they postpone treatment — and in the end, they look for solutions online. That’s where the media buyer is in the right place at the right time.
The niche performs especially well in countries with hot climates, where open footwear is the norm. In summer, the situation worsens: people start noticing yellowing nails, flaking skin, itching between toes. That’s when an offer like “solve the problem in 5 days without doctors or surgery” sounds like salvation. And if the ad also shows what happens if you don’t treat it — the user is already halfway down the funnel.
Visually, creatives in this niche are quite straightforward but provoke a strong emotional reaction. Images of infected nails, cracked skin, swollen feet — and especially “after” shots — are perfect for teaser-style formats. The more discomfort a creative causes, the higher the click-through rate. People respond to raw, honest visuals. You can also approach it from a medical angle: white lab coats, a close-up of an ointment, and a dermatologist confidently saying, “99% of fungal infections are a matter of discipline and the right remedy.”
Landers are usually designed in a medical format — patient testimonials, doctor stories, a clinic where the product was “developed.” Emphasis is placed on natural ingredients, speed of action, and safety. The promise isn’t just to cure the fungus, but to prevent reinfection. Trigger blocks work well: “Fungus can spread to your loved ones,” “One in two people is infected and doesn’t know it,” “Shoes are the perfect incubator for fungus.” All of this heightens anxiety and motivates users to buy immediately.
Psoriasis and eczema are the kind of niches that almost no one in the media buying scene talks about. Yet both conditions are chronic, visible, socially sensitive, and affect millions of people worldwide. It’s perfect ground for nutra: there’s pain, there’s a strong visual trigger, emotional tension, and most importantly — constant demand. Media buyers usually skip over this niche, thinking it’s too medical or hard to package. But take a closer look, and it becomes clear: it has everything needed to build a solid, long-running funnel.
In this case, the media buyer needs to catch the user at a moment when they’re not just suffering but already mentally ready to take action. And that’s not hard — skin conditions almost always have a flare-up nature. For example: cold weather hits, stress kicks in, water changes, a new diet — and suddenly it all flares up again. At that moment, even a simple ad with the message “a remedy that relieves redness and itching” works. If you add real photos of affected skin, “before/after” visuals, and signs of irritation — the user clicks almost on autopilot. This isn’t about fashion or lifestyle; it’s about suffering and relief.
Pseudo-medical framing works especially well in this niche. People expect seriousness: white coats, doctors, lab logos, packaging that looks pharmaceutical. Every element should build trust — not a miracle illusion, but the sense that the product genuinely helps ease symptoms. Promises to “cure” can raise skepticism, but something like “relieves itching and flaking from the first use” looks believable and converts more consistently.
It’s important to understand that psoriasis and eczema are often perceived not just as physical problems but as social stigma. A person with visible plaques on their hands or face may feel isolated. They might be rejected from jobs, or people might avoid them in public. All this creates anxiety and the urge to “be normal” again. Ads that show not just a product, but a journey from discomfort to confidence, from shame to freedom — hit much harder than any generic weight loss or hair growth push.
Balance is key here: you can’t show overly graphic images, especially if running on social platforms. But that doesn’t make the niche weak — it just demands more precise tuning. If you’ve got a solid pre-lander, know how to “embed” the pain into the copy, and your landing page shows not just a “magic cream” but a logical explanation of how it works, with a trust-building flow — the funnel can run for months.
This is where the future of nutra lies — in niches where there’s little noise but real demand. Where users aren’t expecting miracles, but simply want some relief. Where the offer isn’t just a product, but a psychological support system. Psoriasis and eczema aren’t for everyone — but if you know how to sense the pain of your audience and turn it into a packaged solution, this is one of the most rewarding topics in arbitrage.
Emphasize the product’s natural ingredients and its anti-inflammatory effects. Include a doctor’s comment and a “daily improvement timeline” chart. Be sure to mention it’s suitable for children — that expands your target audience.
The reproductive system isn’t just “gynecology” in the broad sense — it’s an entire spectrum of sensitive and deeply personal issues that women regularly face: from irregular cycles and pain to fibroids, inflammation, and fertility struggles. These topics rarely get attention in media buying, because there’s still a taboo and fear of working “on the edge.” But that’s exactly where the potential lies: the quieter the niche, the louder your results can be.
A woman doesn’t always go to the doctor with these kinds of issues. Fear, shame, downplaying her own symptoms, bad past experiences — all of this pushes her to look for solutions on her own. Especially when it comes to something chronic or uncomfortable: irregular cycles, menstrual pain, PCOS, low libido, hormonal imbalances. The internet becomes the first point of contact. Where a man might just buy “strength” vitamins, a woman wants to feel support, trust, and understanding. And if you, as a media buyer, can deliver that — you win.
In this niche, stories perform well. Not just an ad for a supplement, but a narrative — maybe told from the perspective of a woman who faced a similar problem, went through a series of disappointments, and finally found a solution. This format works especially well because women care not only about the result but also about identifying with the protagonist. That’s how the emotional bridge between problem and solution is built. Products in this category aren’t sold aggressively — they are offered with trust and sensitivity. Not “this will fix everything in three days,” but “this can gently support your body when you need it.”
This niche requires a certain visual tone. Aggressive creatives don’t work. What performs well are calm, clean visuals: women’s silhouettes, nature, subtle references to hormonal balance, medical trust, natural ingredients. Arbitrage here is not aggressive but supportive — more like a consultation than a sale. And that works: a woman clicks not because she was shocked, but because she felt understood.
The copy must walk a fine line: don’t promise miracles, but convey hope. Strong blocks include “questions to a gynecologist” and step-by-step explanations of how the product works. Combine natural ingredients with trust-building elements.
Sub-verticals are those niches that aren’t obvious, but hit a very specific pain point. Think parasites, fungus, psoriasis, cystitis, tinnitus, varicose veins, vision or hearing problems. People don’t talk about these openly — but they actively search for solutions. They’re ready to buy right now because they’re suffering — mentally or physically. This is exactly where a media buyer can enter with low competition, capture warm traffic, and get above-average approval rates. The only challenge: avoiding bans at the entry point.
MoreLogin is a multi-account browser that solves the biggest headache in media buying: anti-fraud systems. It allows you to access Facebook or TikTok from dozens of profiles without getting flagged for browser fingerprints, cookies, fonts, language settings, or other traceable parameters. In sub-verticals, calm and scalable operation is key, because approaches vary: psoriasis needs one account setup, parasites another, diabetes yet another. With MoreLogin, all of that can be managed from one interface without worrying about proxies or fingerprints.
If standard nutra verticals are no longer delivering the ROI you’re used to, don’t overlook the less obvious niches. They offer three advantages: lower competition, higher approval rates, and greater trust when the offer is packaged right. The key is not to promise miracles, but to target the real pains and fears of your audience. Creative and landing page are everything.
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